Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
-
Comparative Study
Comparative analysis of the cardioprotective properties of opioid receptor agonists in a rat model of myocardial infarction.
This study was conducted to test the hypothesis that opioid receptor (OR)-mediated cardioprotection is agonist specific when administered prior to coronary artery occlusion and reperfusion in a rat model. ⋯ Peripheral δ₂ OR activation by deltorphin II induces infarct size reduction in this animal model. Agonists of μ, δ₁, κ₁, κ₂, and nociceptin receptors at the doses tested did not induce cardiac tolerance to ischemia/reperfusion injury in vivo.