American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Sep 2011
Randomized Controlled Trial Multicenter Study Comparative StudyRandomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.
β₂-Adrenergic receptor agonists accelerate resolution of pulmonary edema in experimental and clinical studies. ⋯ These results suggest that aerosolized albuterol does not improve clinical outcomes in patients with ALI. Routine use of β₂-agonist therapy in mechanically ventilated patients with ALI cannot be recommended. Clinical trial registered with www.clinicaltrials.gov (NCT 00434993).