American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2012
Comparative StudyTwo microRNA panels to discriminate three subtypes of lung carcinoma in bronchial brushing specimens.
Effective treatment for lung cancer requires accuracy in subclassification of carcinoma subtypes. ⋯ We found two microRNA panels that accurately discriminated between the three subtypes of lung carcinoma in bronchial brushing specimens. The identified microRNA panels may have considerable clinical value in differential diagnosis and optimizing treatment strategies based on lung cancer subtypes.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Letter Review Case ReportsA case of cranial air embolism after transthoracic lung biopsy.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Comparative StudyTrifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer.
Cancer stem cell (CSC) theory has drawn much attention, with evidence supporting the contribution of stem cells to tumor initiation, relapse, and therapy resistance. ⋯ Using in silico drug screening by Connectivity Map followed by empirical validations, we repurposed an existing phenothiazine-like antipsychotic drug, trifluoperazine, as a potential anti-CSC agent that could overcome epidermal growth factor receptor-tyrosine kinase inhibitor and chemotherapy resistance.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Comparative StudyPractice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning.
Carbon monoxide (CO) poisoning is common in modern society, resulting in significant morbidity and mortality in the United States annually. Over the past two decades, sufficient information has been published about carbon monoxide poisoning in the medical literature to draw firm conclusions about many aspects of the pathophysiology, diagnosis, and clinical management of the syndrome, along with evidence-based recommendations for optimal clinical practice. ⋯ The article represents the consensus opinion of four recognized content experts in the field. Supporting data were drawn from the published, peer-reviewed literature on CO poisoning, placing emphasis on selecting studies that most closely mirror clinical practice.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Letter Randomized Controlled Trial Comparative StudyPlasma gelsolin levels in the diagnosis, prognosis, and treatment of lung complications of prematurity.