American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2012
Comparative StudyMitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.
Mechanical ventilation (MV) is associated with adverse effects on the diaphragm, but the cellular basis for this phenomenon, referred to as ventilator-induced diaphragmatic dysfunction (VIDD), is poorly understood. ⋯ Our data suggest that mitochondrial dysfunction lies at the nexus between oxidative stress and the impaired diaphragmatic contractility that develops during MV. Energy substrate oversupply relative to demand, resulting from diaphragmatic inactivity during MV, could play an important role in this process.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Evolution and revolution: the formation of Today's American Thoracic Society, Part 2.
The major event in the recent history of the American Thoracic Society (ATS) is its separation from the American Lung Association (ALA), resulting in the Society's independence. The seeds of the separation were sown over the course of many years. ⋯ Once it was decided that the ATS could only exist as an independent organization, the separation agreement was negotiated in less than 3 years. Although there were substantial unknowns immediately after the separation, a unified leadership, a strongly supportive membership, and a skilled and dedicated staff guided the organization through this difficult period, from which the Society emerged as a strong independent professional organization that remains true to the public-minded spirit that guided its formation 107 years ago.