American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2013
Indoor Pollutant Exposures Modify the Effect of Airborne Endotoxin on Asthma in Urban Children.
The effect of endotoxin on asthma morbidity in urban populations is unclear. ⋯ The effects of household airborne endotoxin exposure on asthma are modified by coexposure to air nicotine and NO2, and these pollutants have opposite effects on the relationships between endotoxin and asthma-related outcomes.
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Am. J. Respir. Crit. Care Med. · Nov 2013
Clinical TrialThe Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma.
The role of airway microbiome in corticosteroid response in asthma is unknown. ⋯ A subset of subjects with CR asthma demonstrates airway expansion of specific gram-negative bacteria, which trigger TAK1/MAPK activation and induce corticosteroid resistance. TAK1 inhibition restored cellular sensitivity to corticosteroids.
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Am. J. Respir. Crit. Care Med. · Nov 2013
Socioeconomic Status and Childhood Asthma in Urban Minority Youths: The GALA II & SAGE II Studies.
The burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact is differentially distributed among racial and ethnic groups. ⋯ Socioeconomic status plays an important role in predicting asthma, but has different effects depending on race and ethnicity. Further steps are necessary to better understand the risk factors through which socioeconomic status could operate in these populations to prevent asthma.