American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2014
Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation.
IL-4Rα, the common receptor component for IL-4 and IL-13, plays a critical role in IL-4- and IL-13-mediated signaling pathways that regulate airway inflammation and remodeling. However, the regulatory mechanisms underlying IL-4Rα turnover and its signal termination remain elusive. ⋯ Our study identified a previously uncharacterized role for STUB1 in regulating IL-4R signaling, which might provide a new strategy for attenuating airway inflammation.