American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2014
Risk Factors and Comorbidities in the Pre-Clinical Stages of Chronic Obstructive Pulmonary Disease.
There is little information about comorbidities and their risk factors in the preclinical stages of chronic obstructive pulmonary disease (COPD). ⋯ Premorbid risk factors and comorbid diseases were more prevalent in the preclinical stages of COPD and smokers without COPD. Physical inactivity and smoking were more strongly associated with the presence of comorbidities compared with airflow obstruction. Clinical trial registered with www.clinicaltrials.gov (NCT 01314807).
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Am. J. Respir. Crit. Care Med. · Jan 2014
Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation.
IL-4Rα, the common receptor component for IL-4 and IL-13, plays a critical role in IL-4- and IL-13-mediated signaling pathways that regulate airway inflammation and remodeling. However, the regulatory mechanisms underlying IL-4Rα turnover and its signal termination remain elusive. ⋯ Our study identified a previously uncharacterized role for STUB1 in regulating IL-4R signaling, which might provide a new strategy for attenuating airway inflammation.