American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2014
Editorial CommentVentilatory facilitation in spinal cord injury.
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Am. J. Respir. Crit. Care Med. · Jan 2014
Humidifier Disinfectant-Associated Children's Interstitial Lung Disease.
Beginning in 2006, epidemics of a fatal lung injury of unknown cause in children were observed in Korea every spring. A recent study demonstrated that this type of children's interstitial lung disease (chILD) is associated with humidifier disinfectant use. ⋯ This study suggests that humidifier disinfectant inhalation causes an idiopathic type of chILD that is characterized by spontaneous air leak, rapid progression, lack of response to treatment, and high mortality. Further safety studies must be performed on common environmental compounds, particularly those that enter the human body by an unusual route.
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Am. J. Respir. Crit. Care Med. · Jan 2014
OSAS affects liver histology and inflammatory cell activation in paediatric NAFLD, regardless of obesity/insulin resistance.
Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in obese children. Whether OSAS and intermittent hypoxia are associated with liver injury in pediatric NAFLD is unknown. ⋯ In pediatric NAFLD, OSAS is associated with biochemical, immunohistochemical, and histological features of NASH and fibrosis. The impact of hypoxemia correction on liver disease severity warrants evaluation in future trials.