American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2014
Multicenter Study Clinical TrialLow titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection.
The biology of fatal pandemic influenza infection remains undefined. ⋯ Early negative A(H1N1) 2009 HI serology can predict death from influenza. This negative serology in fatal cases in young adults reflects the trapping of anti-H1N1 antibodies in immune complexes in the lungs, associated with poor specific helper T-cell response. Clinical trial registered with www.clinicaltrials.gov (NCT 01089400).
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Am. J. Respir. Crit. Care Med. · May 2014
Impact of Pre-Transplant Anti-HLA Antibodies on Outcomes in Lung Transplant Candidates.
The prevalence of anti-HLA antibodies in lung transplant candidates and their impact on waitlist and transplant outcomes is not known. ⋯ The presence of anti-HLA antibodies at the high MFI threshold (>3,000) was associated with lower transplant rate and higher rates of AMR. Screening for anti-HLA antibodies using the 3,000 MFI threshold may be important in managing transplant candidates and recipients.
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Am. J. Respir. Crit. Care Med. · May 2014
Editorial CommentAntibiotics might do more than cause resistance.
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Am. J. Respir. Crit. Care Med. · May 2014
Editorial CommentActive lifestyle: the next "smoking cessation"?