American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2014
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Recent evidence from clinical studies suggests that neutrophil elastase (NE) released in neutrophilic airway inflammation is a key risk factor for the onset and progression of lung disease in young children with cystic fibrosis (CF). However, the role of NE in the complex in vivo pathogenesis of CF lung disease remains poorly understood. ⋯ Our results suggest that NE plays an important role in the in vivo pathogenesis and may serve as a therapeutic target for inflammation, mucus hypersecretion, and structural lung damage and indicate that additional rehydration strategies may be required for effective treatment of airway mucus obstruction in CF.
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Am. J. Respir. Crit. Care Med. · May 2014
Editorial CommentAcute kidney injury: still deadly 10 years later.
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Am. J. Respir. Crit. Care Med. · May 2014
Depression and Risk of Incident Asthma in Adults: The CARDIA Study.
Asthma is associated with depression, but the temporality of the association has not been established. ⋯ This longitudinal observational study points to depression as a marker of risk for incident adult-onset asthma. On the other hand, prevalent asthma is not associated with incident adult-onset depression.
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Am. J. Respir. Crit. Care Med. · May 2014
ReviewAn official american thoracic society/european respiratory society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease.
Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease (COPD) and it has important clinical implications, such as reduced exercise tolerance, quality of life, and even survival. Since the previous American Thoracic Society/European Respiratory Society (ATS/ERS) statement on limb muscle dysfunction, important progress has been made on the characterization of this problem and on our understanding of its pathophysiology and clinical implications. ⋯ Limb muscle dysfunction is a key systemic consequence of COPD. However, there are still important gaps in our knowledge about the mechanisms of development of this problem. Strategies for early detection and specific treatments for this condition are also needed.