American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2014
Randomized Controlled Trial Multicenter Study Comparative StudyA Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock.
Death from infection is a highly heritable trait, yet there are few genetic variants with known mechanism influencing survival during septic shock. ⋯ In European ancestry subjects, the IL1RN variant rs315952C is preferentially transcribed and associated with increased evoked plasma IL1RA and with improved survival from septic shock. It may be that genetically determined IL1RA levels influence survival from septic shock.
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Am. J. Respir. Crit. Care Med. · Sep 2014
Multicenter Study Comparative StudyMulticenter Development and Validation of a Risk Stratification Tool for Ward Patients.
Most ward risk scores were created using subjective opinion in individual hospitals and only use vital signs. ⋯ We developed an accurate ward risk stratification tool using commonly collected electronic health record variables in a large multicenter dataset. Further study is needed to determine whether implementation in real-time would improve patient outcomes.