American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Dec 2015
Close Surveillance with Long-term Follow-up of Subjects with Pre-invasive Endobronchial Lesions.
Autofluorescence bronchoscopy (AFB) and computed tomography (CT) enable lung cancer (LC) detection at the early (pre-)invasive stage. However, LC risk in patients with preinvasive endobronchial lesions is unclear. ⋯ Presence of preinvasive lesions, especially high-grade lesions, may serve as LC risk markers. LCs occur both at preinvasive lesion sites and elsewhere in the bronchial epithelium or lung parenchyma. Prospective validation of biomarkers and randomized intervention studies are needed to determine optimal management strategies.
-
Am. J. Respir. Crit. Care Med. · Dec 2015
Severe Persistent Allergic Rhinitis: Inflammation but No Histologic Features of Structural Upper Airway Remodeling.
Increases in airway smooth muscle, extracellular matrix, and vascularity are prominent features of airway remodeling in asthma, whereas the extent of such remodeling in patients with persistent allergic rhinitis (PAR) is unknown. ⋯ Our data suggest that tissue remodeling is not a feature of PAR and argues that in contrast to asthma, targeting remodeling in allergic rhinitis may not be appropriate as a therapeutic approach.