American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Feb 2015
Historical ArticleTuberculosis in Russia. Its history and its status today.
The history of the Russian tuberculosis (TB) program, dating from the second part of the 19th century until today, is presented, and its achievements and failures are analyzed. The epidemiology of TB is described, and the effects of the TB program initiatives are described and analyzed. Multidrug-resistant TB and HIV coinfection represent severe threats to TB control effectiveness in Russia. New TB control strategies in the present-day epidemiological climate call for important shifts in TB facilities' networking, diagnosis, and treatment approaches.
-
Am. J. Respir. Crit. Care Med. · Feb 2015
Macrophage and Cancer Cell Crosstalk via CCR2 and CX3CR1 is a Fundamental Mechanism Driving Lung Cancer.
Recent studies indicate that tumor-associated macrophages (MΦ) with an M2 phenotype can influence cancer progression and metastasis, but the regulatory pathways remain poorly characterized. ⋯ Tumor-associated MΦ play a central role in lung cancer growth and metastasis, with bidirectional cross-talk between MΦ and cancer cells via CCR2 and CX3CR1 signaling as a central underlying mechanism. These findings suggest that the therapeutic strategy of blocking CCR2 and CX3CR1 may prove beneficial for halting lung cancer progression.