American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2016
Comparative StudyNewborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.
Studies suggest that inappropriate responses to proinflammatory stimuli might contribute to inflammation in cystic fibrosis (CF) lungs. However, technical challenges have made it difficult to distinguish whether altered responses in CF airways are an intrinsic defect or a secondary effect of chronic disease in their tissue of origin. The CF pig model provides an opportunity to study the inflammatory responses of CF airways at birth, before the onset of infection and inflammation. ⋯ Transcriptome profiling suggests that acute inflammatory responses are dysregulated in the airways of newborn CF pigs.
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Am. J. Respir. Crit. Care Med. · Oct 2016
Mechanisms of Chronic Muscle Wasting and Dysfunction After an Intensive Care Unit Stay: A Pilot Study.
Critical illness survivors often experience permanent functional disability due to intensive care unit (ICU)-acquired weakness. The mechanisms responsible for long-term weakness persistence versus resolution are unknown. ⋯ Long-term weakness in ICU survivors results from heterogeneous muscle pathophysiology with variable combinations of muscle atrophy and impaired contractile capacity. These findings are not explained by ongoing muscle proteolysis, inflammation, or diminished mitochondrial content. Sustained muscle atrophy is associated with decreased satellite cell content and compromised muscle regrowth, suggesting impaired regenerative capacity.