American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2016
Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications After Lung Transplantation.
Central airway stenosis (CAS) after lung transplantation has been attributed in part to chronic airway ischemia; however, little is known about the time course or significance of large airway hypoxia early after transplantation. ⋯ These findings implicate donor bronchial hypoxia as a driving factor for post-transplantation airway complications. Strategies to improve airway oxygenation, such as bronchial artery re-anastomosis and hyperbaric oxygen therapy merit clinical investigation.
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Am. J. Respir. Crit. Care Med. · Mar 2016
Outcome of Patients with Interstitial Lung Disease Treated with Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.
Patients with interstitial lung disease and acute respiratory failure have a poor prognosis especially if mechanical ventilation is required. ⋯ ECMO is a lifesaving option for patients with interstitial lung disease and acute respiratory failure provided they are candidates for lung transplantation. ECMO is not able to reverse the poor prognosis in patients that do not qualify for lung transplantation.