American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Apr 2016
Oxidative Modifications of Protein Tyrosyl Residues are Increased in Plasma of Human Subjects with Interstitial Lung Disease.
Interstitial lung diseases (ILDs) are associated with oxidative stress. Plasma biomarkers that are directly linked to oxidative stress responses in this disease have not been identified. Stable oxidation products of tyrosine residues in proteins may reflect the oxidative microenvironment in the lung or a systemic inflammatory state. ⋯ We demonstrate an increase in oxidized tyrosine moieties within proteins in the circulating plasma of patients with ILD. These data support the potential for development of oxidative stress-related biomarkers in early diagnosis, prognostication, and/or in evaluating responsiveness to emerging therapies for ILD.