American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2016
HIP1 is an Early-stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated EMT.
Non-small cell lung cancer (NSCLC) carries a poor survival rate mainly because of metastasis. However, the molecular mechanisms that govern NSCLC metastasis have not been described. Because huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis, we tested the involvement of HIP1 in NSCLC progression and metastasis. ⋯ HIP1 serves as an early-stage prognostic biomarker and a metastatic suppressor. Reduced expression during AdCA progression can relieve HIP1 suppression of Akt-mediated epithelial-mesenchymal transition and thereby lead to development of late metastases and poor prognosis.
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Am. J. Respir. Crit. Care Med. · Apr 2016
Membrane-anchored Serine Protease Matriptase is a Trigger of Pulmonary Fibrogenesis.
Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies. ⋯ These results implicate increased matriptase expression and activity in the pathogenesis of pulmonary fibrosis in human IPF and in an experimental mouse model. Overall, targeting matriptase, or treatment by CM, which is already in clinical use for other diseases, may represent potential therapies for IPF.