American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2016
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-catenin.
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, the mechanisms by which FAM13A contributes to COPD susceptibility are unknown. ⋯ We show that FAM13A may influence COPD susceptibility by promoting β-catenin degradation.