American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2016
Circulating Cell Death Biomarkers May Predict Survival in Human Lung Transplantation.
Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. ⋯ Recipient plasma concentration of epithelial cell death markers (M30, M65) after lung transplantation is negatively correlated with early graft performance and long-term survival.
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Am. J. Respir. Crit. Care Med. · Jul 2016
Randomized Controlled TrialEffect of Anti-IL-13 Treatment on Airway Dimensions in Severe Asthma.
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Am. J. Respir. Crit. Care Med. · Jul 2016
Toll-like Receptor 7 is Reduced in Severe Asthma and Linked to Altered MicroRNA Profile.
Asthma is one of the most common chronic diseases worldwide, and individuals with severe asthma experience recurrent exacerbations. Exacerbations are predominantly viral associated and have been linked to defective airway IFN responses. Ascertaining the molecular mechanisms underlying this deficiency is a major research goal to identify new therapeutic targets. ⋯ In severe asthma, TLR7 deficiency drives impaired innate immune responses to virus by AMs. Blocking a group of microRNAs that are up-regulated in these cells can restore antiviral innate responses, providing a novel approach for therapy in asthma.
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Am. J. Respir. Crit. Care Med. · Jul 2016
Galectin-3 is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities.
Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis in experimental studies, and Gal-3 levels have been found to be elevated in small studies of human pulmonary fibrosis. ⋯ Elevated Gal-3 concentrations are associated with interstitial lung abnormalities coupled with a restrictive pattern, including decreased lung volumes and altered gas exchange. These findings suggest a potential role for Gal-3 in early stages of pulmonary fibrosis.