American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2017
Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.
Chronic obstructive pulmonary disease (COPD) is characterized by impaired clearance of pulmonary bacteria. ⋯ Up-regulation of Mcl-1 and chronic adaption to oxidative stress alter mitochondrial metabolism and microbicidal function, reducing the delayed phase of intracellular bacterial clearance in COPD.