American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2017
The Timing of Early Antibiotics and Hospital Mortality in Sepsis.
Prior sepsis studies evaluating antibiotic timing have shown mixed results. ⋯ In a large, contemporary, and multicenter sample of patients with sepsis in the emergency department, hourly delays in antibiotic administration were associated with increased odds of hospital mortality even among patients who received antibiotics within 6 hours. The odds increased within each sepsis severity strata, and the increased odds of mortality were greatest in septic shock.