American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2017
Randomized Controlled Trial Multicenter StudyHome Monitoring in CF to Identify and Treat Acute Pulmonary Exacerbations: eICE Study Results.
Individuals with cystic fibrosis (CF) experience frequent acute pulmonary exacerbations, which lead to decreased lung function and reduced quality of life. ⋯ An intervention of home monitoring among patients with CF was able to detect more exacerbations than usual care, but this did not result in slower decline in lung function. Clinical trial registered with www.clinicaltrials.gov (NCT01104402).
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Am. J. Respir. Crit. Care Med. · Nov 2017
Randomized Controlled TrialEffect of Emphysema Extent on Serial Lung Function in Patients with Idiopathic Pulmonary Fibrosis.
Patients with idiopathic pulmonary fibrosis and emphysema may have artificially preserved lung volumes. ⋯ FVC measurements may not be appropriate for monitoring disease progression in patients with idiopathic pulmonary fibrosis and emphysema extent greater than or equal to 15%.
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Am. J. Respir. Crit. Care Med. · Nov 2017
ReviewFifty Years of Research in ARDS. Genomic Contributions and Opportunities.
Clinical factors alone poorly explain acute respiratory distress syndrome (ARDS) risk and ARDS outcome. In the search for individual factors that may influence ARDS risk, the past 20 years have witnessed the identification of numerous genes and genetic variants that are associated with ARDS. ⋯ More recently, methodologies of causal inference are being applied to maximize the information gained from genetic associations. Although challenges of sample size, both recognized and unrecognized phenotypic heterogeneity, and the paucity of early ARDS lung tissue limit some applications of the rapidly evolving field of genomic investigation, ongoing genetic research offers unique contributions to elucidating ARDS pathogenesis and the paradigm of precision ARDS medicine.