American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2017
A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in COPD.
Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. ⋯ Patients with COPD and/or CS-exposed mice have pulmonary and renal endothelial cell injury linked to increased endothelial cell AGEs and RAGE levels. Albuminuria could identify patients with COPD in whom angiotensin-converting enzyme inhibitor therapy improves renal and lung function by reducing endothelial injury.