American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2018
Comparative StudyMicrobial Lineages in Sarcoidosis: A Metagenomic Analysis Tailored for Low Microbial Content Samples.
The etiology of sarcoidosis is unknown, but microbial agents are suspected as triggers. ⋯ Metagenomic sequencing revealed enrichment of microbes in single types of sarcoidosis samples but limited concordance across sample types. Statistical analysis accounting for environmental contamination was essential to avoiding false positives.
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Am. J. Respir. Crit. Care Med. · Jan 2018
Comparative StudyMechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.
Diaphragm dysfunction worsens outcomes in mechanically ventilated patients, but the clinical impact of potentially preventable changes in diaphragm structure and function caused by mechanical ventilation is unknown. ⋯ Diaphragm atrophy developing during mechanical ventilation strongly impacts clinical outcomes. Targeting an inspiratory effort level similar to that of healthy subjects at rest might accelerate liberation from ventilation.