American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2018
Pulmonary Vasodilator Therapy in Shock-associated Cardiac Arrest.
Many in-hospital cardiac arrests are precipitated by hypotension, often associated with systemic inflammation. These patients are less likely to be successfully resuscitated, and novel approaches to their treatment are needed. ⋯ The addition of iNO to HD-CPR in LPS-induced shock-associated cardiac arrest improved short-term survival and intraarrest hemodynamics.
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Am. J. Respir. Crit. Care Med. · Apr 2018
Cardiovascular and Neuropsychiatric Events after Varenicline Use for Smoking Cessation.
Varenicline aids in smoking cessation but has also been associated with serious adverse events. ⋯ Varenicline appears to be associated with an increased risk of cardiovascular but not neuropsychiatric events.
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Am. J. Respir. Crit. Care Med. · Apr 2018
Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma.
Inflammation and smooth muscle dysfunction are integral components of severe asthma that contribute to luminal obstruction causing airflow limitation, ventilation heterogeneity, and symptoms. This is important for guiding treatment decisions directed at the inflammatory (e.g., anti-T-helper cell type 2 monoclonal antibodies) and noninflammatory, smooth muscle-mediated (e.g., bronchial thermoplasty) components of severe asthma. ⋯ In patients with severe asthma, MRI regionally identifies the inflammatory and noninflammatory components of airway disease. Ventilation heterogeneity persists postsalbutamol in patients with uncontrolled eosinophilic bronchitis, which may be the functional consequence of airway inflammation.