American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2018
Randomized Controlled Trial Comparative StudyLong-Term Outcomes after Protocolized Sedation versus Usual Care in Ventilated Pediatric Patients.
Whether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown. ⋯ A sedation strategy that allows patients to be more awake and exposes them to fewer sedative and analgesic medications produces no long-term harm. However, postdischarge morbidity after acute respiratory failure is common. Clinical trial registered with www.clinicaltrials.gov (NCT00814099).