American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2019
Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.
CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases. ⋯ Our findings support clinical observations by providing evidence that lack of CC16 in the lung results in dramatically altered pulmonary function and structural alterations consistent with enhanced remodeling.
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Am. J. Respir. Crit. Care Med. · Feb 2019
Editorial CommentCOPD: Shifting the Paradigm to the Vasculature.