American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2019
Letter Randomized Controlled TrialTwo Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization.
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Am. J. Respir. Crit. Care Med. · May 2019
Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.
Rationale: Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene expression, supporting a role for lung microbiota in IPF. However, the causal significance of altered lung microbiota in disease progression is undetermined. ⋯ Conclusions: Our results demonstrate that lung microbiota contribute to the progression of IPF. We provide biological plausibility for the hypothesis that lung dysbiosis promotes alveolar inflammation and aberrant repair. Manipulation of lung microbiota may represent a novel target for the treatment of IPF.