American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2020
Randomized Controlled TrialCirculating MicroRNAs and Treatment Response in Childhood Asthma.
Rationale: Inhaled corticosteroids (ICS) are key treatments for controlling asthma and preventing asthma attacks. However, the responsiveness to ICS varies among individuals. MicroRNAs (miRNAs) have been lauded for their prognostic utility. ⋯ We selected three miRNAs for functional validation, of which hsa-miR-155-5p and hsa-miR-532-5p were significantly associated with changes in dexamethasone-induced transrepression of NF-κB. Combined, these two miRNAs were predictive of ICS response over the course of the clinical trial, with an area under the receiver operating characteristic curve of 0.86. Conclusions: We identified two functional circulating miRNAs predictive of asthma ICS treatment response over time.
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Am. J. Respir. Crit. Care Med. · Jul 2020
Letter Case ReportsCOVID-19 Associated Pulmonary Aspergillosis.