American journal of respiratory and critical care medicine
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Ahead of Print article withdrawn by publisher.
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Ahead of Print article withdrawn by publisher.
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Am. J. Respir. Crit. Care Med. · May 2022
Randomized Controlled TrialImpact of Exposure to Diesel Exhaust on Inflammation Markers and Proteases in Former Smokers with COPD: A Randomized, Double-Blinded, Crossover Study.
Rationale: There is growing evidence that chronic obstructive pulmonary disease (COPD) can be caused and exacerbated by air pollution exposure. Objectives: To document the impact of short-term air pollution exposure on inflammation markers, proteases, and antiproteases in the lower airways of older adults with and without COPD. Methods: Thirty participants (10 ex-smokers with mild to moderate COPD and 20 healthy participants [9 ex-smokers and 11 never-smokers]), with an average age of 60 years, completed this double-blinded, controlled, human crossover exposure study. ⋯ Circulating lymphocytes were increased after DE exposure (0.14 [95% CI, 0.05-0.24] cells × 109/L; P = 0.03), irrespective of COPD status. Conclusions: A controlled human crossover study of DE exposure reveals that former smokers with COPD may be susceptible to an inflammatory response compared with ex-smokers without COPD or never-smoking healthy control participants. Clinical trial registered with www.clinicaltrials.gov (NCT02236039).