American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2024
Editorial Comment LetterA Novel CT Score Reveals More About Air Trapping in Asthma.
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Am. J. Respir. Crit. Care Med. · May 2024
Multicenter StudyCommensal Oral Microbiota, Disease Severity and Mortality in Fibrotic Lung Disease.
Rationale: Oral microbiota associate with diseases of the mouth and serve as a source of lung microbiota. However, the role of oral microbiota in lung disease is unknown. Objectives: To determine associations between oral microbiota and disease severity and death in idiopathic pulmonary fibrosis (IPF). ⋯ The Streptococcus genus was mainly composed of Streptococcus mitis species. Conclusions: Increasing buccal microbial diversity predicts disease severity and death in IPF. The oral commensal S. mitis spp associates with preserved lung function and improved survival.
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Am. J. Respir. Crit. Care Med. · May 2024
Proteomic Biomarkers of Survival in Idiopathic Pulmonary Fibrosis.
Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To identify and validate circulating protein biomarkers of IPF survival. ⋯ In decision curve analysis, a proteomic signature of TFS outperformed a similarly derived clinical prediction model. Conclusions: In the largest proteomic investigation of IPF outcomes performed to date, we identified and validated 140 protein biomarkers of TFS. These results shed important light on potential drivers of IPF progression.