American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med.
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Am. J. Respir. Crit. Care Med. · Jan 2024
Multicenter StudyThe Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.
Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives: We aimed to more accurately assess the impact of donor smoke exposure on PGD and mortality using quantitative smoke exposure biomarkers. ⋯ Conclusions: Donor smoking associates with a modest increase in PGD risk but not with increased recipient mortality. Use of lungs from smokers is likely safe and may increase lung donor availability. Clinical trial registered with www.clinicaltrials.gov (NCT00552357).