American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med.
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Am. J. Respir. Crit. Care Med. · Dec 2023
Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD.
Within chronic obstructive pulmonary disease (COPD), emphysema is characterized by a significant yet partially understood B cell immune component. ⋯ An off-targeted B cell activation within LFs is associated with autoimmune-mediated emphysema pathogenesis.