American journal of respiratory and critical care medicine
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Chronic obstructive pulmonary disease (COPD) is a heterogenous lung condition characterized by progressive airflow obstruction. Despite advancements in diagnosis and treatment, the disease burden remains high; although clinical trials have shown improvements in outcomes such as exacerbations, quality of life, and lung function, improvement may not be attainable for many patients. For patients who do experience improvement, it is challenging to set management goals given the progressive nature of COPD. ⋯ Here we propose a preliminary definition of disease stability, informed by existing research in COPD. Further research will be needed to validate the framework for use in clinical and research settings. Exploring disease stability as a goal, however, is an opportunity to develop and validate an attainable treatment target to advance the standard of care for patients with COPD.
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Am. J. Respir. Crit. Care Med. · Dec 2024
Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients.
High flow therapy reduces dyspnea in acute respiratory failure but the underlying mechanisms are not fully elucidated. ⋯ In orally intubated patients, nasal high flow was associated with lower dyspnea and lower respiratory drive without affecting the inspiratory work.