Croatian medical journal
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Croatian medical journal · Aug 2006
Historic exposure to plague and present-day frequency of CCR5del32 in two isolated island communities of Dalmatia, Croatia.
To assess the frequency of deletion of 32 base pairs in a CCR5 gene, shown to confer resistance to HIV infection, in two isolated island communities of Dalmatia, Croatia, with different histories of exposure to (plague) during the medieval period and beyond. ⋯ This study does not rule out the possible role of plague in positive selection at CCR5del32. However, analyses of further neighboring isolated island communities need to be made in order to provide more substantial support for this hypothesis.