Croatian medical journal
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Croatian medical journal · Aug 2022
Case ReportsImmune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication.
Since the beginning of mass vaccination against coronavirus disease 2019 (COVID-19), vaccine-linked immune-mediated diseases have been increasingly reported. The development of these diseases after COVID-19 vaccination may be attributed to the mechanisms of molecular mimicry and cross-reactivity between the viral spike protein and self-antigens. The most frequent vaccine-linked glomerular disease is immunoglobulin A nephropathy (IgAN). ⋯ The temporal association between vaccination and disease development in the absence of other possible intercurrent inciting events suggests a causal mechanism, although coincidental co-occurrence cannot be excluded. In both cases, immunosuppressive treatment was warranted to stop disease progression and to partially or completely resolve the disease. A timely reaction is needed if new-onset signs of an immune-mediated disease appear after vaccination.
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Croatian medical journal · Aug 2022
Results of the National Breast Cancer Screening Program in Croatia (2006-2016).
To assess the uptake of the Croatian National Breast Cancer Screening Program from 2006 to 2016. ⋯ The National Breast Cancer Screening Program in Croatia reached a substantial proportion of the target group. Yet, additional efforts are needed to reach at least 70% of the target population.
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Croatian medical journal · Aug 2022
The burden of viral lower respiratory tract infections during the neonatal period: six-year experience at a tertiary referral hospital.
To identify the epidemiological and clinical features of acute viral lower respiratory tract infections (LRTI) caused by respiratory syncytial virus and other respiratory viruses, and to determine the risk factors for the severe disease among neonates. ⋯ The burden of respiratory syncytial virus LRTI in the neonatal period is high, although other respiratory viruses can also cause a severe respiratory disease. In preterm infants, rhinovirus infection presents an important risk factor for a severe course of LRTI with complications. Infection with two respiratory viruses leads to a more severe clinical course.
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Croatian medical journal · Aug 2022
Case ReportsVascular Ehlers-Danlos syndrome, an often unrecognized clinical entity: a case report of a novel mutation in the COL3A1 gene.
Due to life-threatening complications, vascular Ehlers-Danlos syndrome (vEDS) is the most severe form of EDS. Because the syndrome is associated with a shortened life expectancy and variable clinical presentation, diagnosis confirmed by genetic testing is crucial to determining appropriate treatment. Despite some distinguishing features, this rare disease often goes unrecognized. ⋯ The diagnosis of vEDS was established based on clinical manifestations and confirmed by genetic testing. A novel heterozygous pathogenic variant in the COL3A1 gene was found. To our knowledge, this is the first case of vEDS caused by this variant.
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Croatian medical journal · Aug 2022
More slices, less truth: effects of different test-set design strategies for magnetic resonance image classification.
To assess the effects of different test-set design strategies for magnetic resonance (MR) image classification using deep learning. ⋯ When deep learning is applied to MR image classification, training and test sets should consist of MR images of different patients. Models built on training and test sets consisting of images of the same patients yield optimistic error rates and lead to wrong conclusions. MR images of neighboring slices are so similar that they cause data leakage effect.