Croatian medical journal
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Croatian medical journal · Apr 2024
The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.
To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors. ⋯ mtDNA mutations negatively affected the survival outcomes of Malaysian patients with primary brain tumors. However, studies with larger samples are needed to confirm the association between mutation burden and survival rates.