Croatian medical journal
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Croatian medical journal · Apr 2024
Factors contributing to variability in metformin concentration in polycystic ovary syndrome.
To investigate the factors affecting metformin concentrations after chronic administration in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for personalized therapy. ⋯ This study highlights the critical role of BMI in influencing metformin pharmacokinetics in PCOS patients and underscores the need for personalized treatment strategies in patients with PCOS.
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Croatian medical journal · Apr 2024
Exploring ChatGPT's abilities in medical article writing and peer review.
To evaluate the quality of ChatGPT-generated case reports and assess the ability of ChatGPT to peer review medical articles. ⋯ While ChatGPT demonstrated proficiency in generating case reports, there were limitations in terms of consistency and accuracy, especially in referencing.
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Croatian medical journal · Apr 2024
Innovative statistical approaches: the use of neural networks reduces the sample size in the splenectomy-MCAO mouse model.
To compare the effectiveness of artificial neural network (ANN) and traditional statistical analysis on identical data sets within the splenectomy-middle carotid artery occlusion (MCAO) mouse model. ⋯ This study validated the neuroprotective impact of splenectomy in an MCAO model using ANN for data analysis with a reduced animal sample size, demonstrating the potential for leveraging advanced statistical methods to minimize sample sizes in experimental biomedical research.
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Croatian medical journal · Apr 2024
The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.
To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors. ⋯ mtDNA mutations negatively affected the survival outcomes of Malaysian patients with primary brain tumors. However, studies with larger samples are needed to confirm the association between mutation burden and survival rates.