Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
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Newer imaging modalities, such as 18F-FDG PET/CT and 99mTc-MIBI scintigraphy, have been recently introduced to assess the activity and extent of disease in patients with multiple myeloma (MM) and gammopathy of undetermined significance (MGUS). The aim of our study was to compare the impact of these imaging modalities in the evaluation of MM and MGUS patients. ⋯ 18F-FDG PET/CT appeared to be a better imaging technique than 99mTc-MIBI scintigraphy in the detection of focal lesions in patients with symptomatic MM. 99mTc-MIBI was superior in the visualization of diffuse disease. On the other hand, despite its limited capacity in detecting focal lesions, 99mTc-MIBI scintigraphy still remains the most rapid and inexpensive technique for whole-body evaluation and may be an alternative option when a PET/CT facility is not available.
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Locally advanced breast carcinoma represents a disease, where the combination of treatment--chemotherapy with antracycline and radiotherapy--is generally accepted as standard therapy. This management can be limited by cardiotoxicity. Cardiotoxicity is a rare complication of breast cancer treatment and the incidence and severity of cardiotoxicity are dependent on cumulative dose of antracyline, the type and combination of drugs used, the presence of coexsistin diseases (cardiac diseases, diabetes mellitus), risk faktors and use, the way of radiotherapy and combination therapy in the treatment of locally advanced breast carcinoma. ⋯ The incidence of the risk of cardiotoxicity is rare event but the risk of damage to the cardiovascular system following radiotherapy and antracyclines exists, although cardiotoxic effects of both these drugs groups have been well known. The cardiotoxicity apperas in the process of the chemotherapy with doxorubicine, in combination of the chemotherapy with doxorubicine and radiotherapy, but also in longer time intervals from the beginning of the treatment (2, 3, 4, 5 and more years).
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Multicenter Study
[IKARUS Project--incidence of bone events in breast cancer: retrospective analysis of patients in oncological centres in the Czech Republic and Slovakia].
Bone incidents today represent, in terms of frequency and the overall effect on the quality of life of patients with breast cancer, a serious health problem. In a number of clinical studies bisphosphonates have been shown to have a positive impact on reducing the risk of bone events and therefore to be effective in the prevention of bone events. The primary objective of this project was to identify the incidence of bone events in patients with metastatic breast cancer treated in the Czech and Slovak Republics. ⋯ This work has shown that the practice of treatment with bisphosphonates since 2000 and assessed the survival of patients with metastatic breast cancer.
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Multicenter Study
[Experience in data management of the clinical retrospective project in Czech and Slovak oncology centres (IKARUS Project)].
The retrospective part of the IKARUS Project (Incidence of Skeletal Related Events in Breast Cancer) was focused on monitoring the incidence of skeletal related events in patients with metastatic breast cancer treated in the Czech and Slovak Republics.The aim was to describe the experience with data collection management in the conditions of the Czech and Slovak Republics. ⋯ The binding methodical conclusion is that unless a systemic change is made in the functionality of hospital information systems and standardised electronic documentation is introduced, the retrospective collection of clinical data in our conditions will be associated with high costs and a relatively low recovery factor.
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Cancer metastasis to skeletal muscle is very rare. Lung cancer, renal cell carcinoma and malignant melanoma have been reported as the most frequent primary tumours. Diagnosis of muscle metastasis from other primary cancer sites is more than problematic. ⋯ Thus, among the different imaging techniques, FDG PET/CT enables the detection of metabolically highly active tumour cells, undetectable by other conventional imaging means.