Journal of the American College of Surgeons
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Immunotherapy has achieved effective antitumor activity in advanced GC patients. However, the rate of response to ICI therapy is disappointing, T cell exhaustion may contribute to this phenomenon. EBI3 is an emerging immunosuppressive factor, and the association between EBI3 and T cell exhaustion is not clear. In this study, we aimed to explore the expression of EBI3 in GC, and reveal the function of EBI3 in T cell exhaustion. ⋯ Our study indicated that EBI3 is an important cytokine in the development of GC, and EBI3 may promote the development of GC by inducing T cell exhaustion in the tumor microenvironment.