Seminars in respiratory and critical care medicine
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The lung allocation score (LAS) was developed in an effort to facilitate lung transplantation to more urgent and ill patients, to decrease wait time, and to change the allocation process to a more merit-based system. Four years after the implementation of the LAS, we now evaluate the impact and outcomes of this system. We have found that registrations on the wait list as well as wait time have decreased. ⋯ There has been significant change in the distribution of diagnoses receiving transplantation with no significant difference in survival in most areas. Patients with higher LAS scores have increased short-term mortality. The LAS has affected the allocation process as well as significant outcomes in the transplant patient population.
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Invasive fungal infections, especially candidemia and systemic candidiasis, have become a major cause of morbidity and mortality in the last few decades. This comes in parallel with the major advances made in intensive care. Patients who are critically ill, in medical or surgical ICUs are especially at risk for CANDIDA infections. ⋯ Despite these advancements, the mortality rates associated with candidiasis remain excessively high, with an overall mortality in the range of 30 to 50% and an attributable mortality of ~30%. In addition to this high case-fatality rate, candidemia is also associated with a substantial economic burden, primarily due to an extended length of stay. Strategies to evaluate either the prevention, early diagnosis, or initiation of appropriate therapy should yield both clinical and socioeconomic benefits.
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Outcomes research is a life sciences field that focuses on patient-oriented outcomes, which are important to a wide range of stakeholders, including patients, physicians, health care systems and payers, and society. An important emphasis of outcomes research is assessment of medical processes and interventions in "real world" settings rather than under experimental conditions. A condition of this approach is that many studies are observational in design. ⋯ Controversial topics in respiratory diseases such as intensive care unit (ICU) organization and relationships of hospital volume to patient mortality are discussed to illustrate how different study designs and analytic techniques can lead to discrepant study results. Outcomes research will increase in importance and application as health care systems and payers become more interested in maximizing patient outcomes relative to resources used. Resources should be made available to enhance the training of new investigators and provide sufficient expertise for the design and analysis of influential studies.
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Semin Respir Crit Care Med · Feb 2010
ReviewLong-term outcomes in patients surviving acute respiratory distress syndrome.
Recent studies have begun to describe the long-term outcomes of acute respiratory distress syndrome (ARDS) survivors. These patients experience several physical, mental, and psychological morbidities that significantly impair their health-related quality of life (HRQL). ⋯ Future research should focus on the early identification of patients and their family members at risk for long-term sequelae, the mechanisms of injury leading to long-term ARDS consequences, and therapeutic modalities designed to prevent or decrease these morbidities. Clinicians, caregivers, and patients should be made aware of the deleterious long-term effects of the intensive care unit stay because they are currently poorly recognized and potentially modifiable.