Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
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Patients with traumatic subdural hygroma (SDG) are at an increased risk of developing chronic subdural hematoma (CSDH). However, the mechanism by which this occurs is still not fully understood. The purpose of this paper is to investigate the clinical characteristics and pathogenesis of CSDH, as well as the relationship between CSDH and SDG. ⋯ All patients underwent an operation, which resulted in good recovery in all but one case. The cycle of persistent SDG, rebleeding, coagulation and fibrinolysis contributes to the development of CSDH from SDG. It is important to understand the natural history of CSDH and carefully follow up patients with head injury, especially if it is associated with SDG, and the potential for the development of CSDH should be considered.
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Trigeminal schwannomas (TS) are rare. Only a couple of series involving a large number of cases have been reported. In the present study we aimed to analyse the clinical characteristics of TS, the surgical approaches used to treat TS, and the outcomes for patients undergoing surgical treatment for TS via retrospective analysis of departmental records. ⋯ Follow-up ranged from 3 months to 12 years (mean 62 months). One patient died and nine (15%) had permanent morbidity in the form of corneal opacity (5) or facial (2) or trochlear (2) nerve palsy. We conclude that trigeminal neuromas are best treated by total surgical resection, which yields acceptable results with low rates of mortality and permanent morbidity.
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Cervical radiculopathy caused by a posterolateral disc herniation or spondylosis is a common pathology. Decompression of a stressed cervical nerve root is a routine neurosurgical procedure. To determine the safety and effectiveness of anterior cervical microforaminotomy (ACM), we prospectively studied patients undergoing this treatment at our institution to determine the efficacy of the approach for the treatment of unilateral cervical spondylotic or discogenic radiculopathy. ⋯ ACM appears to be a good alternative procedure, and a good non-fusion disc-preserving technique. Disc and bone resections are minimal in carefully selected patients with unilateral cervical radiculopathy. This method avoids osteoarthrodesis or arthroplasty with disc prostheses.
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The aim of this study was to determine the features and prevalence of primary stabbing headache, primary exertional headache, primary headache associated with sexual activity, and primary cough headache in a Turkish population of headache patients. The data for this study were obtained from 245 patients with headache. Of these patients, 55 fulfilled the International Classification of Headache Disorders (second edition) diagnostic criteria for 'other primary headaches' such as primary stabbing headache (n=31), primary cough headache (n=1), primary exertional headache (n=13), primary headache associated with sexual activity (n=4), and both primary cough headache and primary exertional headache (n=6). Primary stabbing headache was found in 12.6% of patients, primary cough headache in 0.4%, primary exertional headache in 5.3% and primary headache associated with sexual activity in 1.6%.
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In this study we evaluated the effect of donepezil on the neurodegeneration and behavioral impairments induced by mild traumatic brain injury (MTBI). Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. ⋯ Treatment with a single oral dose of donepezil (12mg/kg) immediately after injury significantly attenuated MTBI-induced neuronal death and cognitive impairment as measured by preservation of neurons in the CA1 region of the hippocampus and a water maze test respectively. However, these neuroprotective effects were prevented by concomitant injection of mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection is mediated by nAChR activation.