Journal of travel medicine
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Multicenter Study
Doxycycline responding illnesses in returning travellers with undifferentiated non-malaria fever: a european multicenter prospective cohort study.
Diagnosis of undifferentiated non-malaria fevers (NMF) in returning travellers is a great challenge. Currently, there is no consensus about the use of empirical antibiotics in returning travellers with undifferentiated NMF. Although studies in endemic areas showed that a wide range of pathogens implicated in undifferentiated NMF are treatable with doxycycline, the role of doxycycline in returning travellers with fever still has to be explored. ⋯ Although DRI are responsible for 30% of undifferentiated NMF cases in travellers, those are seldom recognized during the first clinical encounter. Empirical treatment with doxycycline should be considered in returning travellers with undifferentiated fever and negative tests for malaria and dengue, particularly when presenting severe illness, predictive factors for rickettsiosis or no features of dengue.
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As COVID-19 vaccine roll-out begins in the MENA region, ensuring that migrant populations have equitable access to the vaccine, designing innovative and specific mechanisms for vaccine roll-out in these areas and monitoring vaccine uptake in migrant groups are now imminent challenges.