Academic radiology
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Comparative Study
Liver fat quantification by dual-echo MR imaging outperforms traditional histopathological analysis.
The aim of this study was to evaluate the accuracy of dual-echo (DE) magnetic resonance imaging (MRI) with and without fat and water separation for the quantification of liver fat content (LFC) in vitro and in patients undergoing liver surgery, with comparison to histopathologic analysis. ⋯ DE MRI allows the accurate quantification of LFC in a surgical population, outperforming traditional histopathologic analysis. DE MRI without fat and water separation shows the highest accuracy and smallest measurement bias for the quantification of LFC.
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The purpose is to perform outcomes-based assessment of a new reference standard for delayed cerebral ischemia (DCI) related to vasospasm. ⋯ This new reference standard has high diagnostic accuracy for DCI related to vasospasm. The outcomes-based assessment further supports its accuracy in correctly classifying A-SAH patients.
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The field of medical education research is growing rapidly, but educational research has been widely criticized for its lack of a scientific approach, poor theoretical frameworks or study designs, deficient research methods and reporting quality, and lack of meaningful outcomes that would inform practice. There have been recent calls for greater accountability and return on investment for all research efforts and clinical practice. The impact of medical education on important health outcomes such as patient care is unclear but likely underestimated. ⋯ A structured guideline is suggested and provided for interested readers and reviewers of educational research. Although there are challenges to be faced, they provide endless possibilities to expand and improve on medical education research and to bring it to its full fruition, alongside traditional clinical research. Education is critical to important outcomes, and a greater emphasis should be placed on understanding medical education research.
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Quantitative measurement provides essential information about disease progression and treatment response in patients with glioblastoma multiforme (GBM). The goal of this article is to present and validate a software pipeline for semi-automatic GBM segmentation, called AFINITI (Assisted Follow-up in NeuroImaging of Therapeutic Intervention), using clinical data from GBM patients. ⋯ Validation results using clinical GBM data showed high correlation between the AFINITI results and manual annotation. Compared to the voxel-wise segmentation, AFINITI yielded more accurate results in segmenting the enhanced GBM from multimodality MR imaging data. The proposed pipeline could be used as additional information to interpret MR brain images in neuroradiology.
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Controlled Clinical Trial
Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease.
The objective of this study was to evaluate the tolerability of hyperpolarized (129)Xe gas inhaled from functional residual capacity and magnetic resonance imaging in healthy subjects and those with pulmonary disease. ⋯ Inhalation of hyperpolarized (129)Xe gas and subsequent magnetic resonance imaging were well tolerated in healthy subjects and ambulatory subjects with obstructive and restrictive pulmonary disease.