European journal of emergency medicine : official journal of the European Society for Emergency Medicine
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Letter Case Reports
Analgesia and sedation in the presence of a naltrexone implant: a novel pharmacological challenge.
In chronic opioid abusers, sedation and analgesia present challenges. We describe two trauma patients with naltrexone implants (depot micro-receptor antagonists that facilitate opioid withdrawal) requiring intensive care. The first patient, a 28-year-old man, sustained chest and pelvic injuries when hit by a motor vehicle. ⋯ Propofol, tramadol and paracetamol proved effective. We wish to notify colleagues of the existence of these implants as they are increasingly widely used, and should be considered when encountering severe opioid resistance. Secondly, their role in managing opioid-dependent physicians appears promising.
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The drugs N-acetylcysteine and erdosteine were used to evaluate their protective effects in hemorrhagic shock-induced acute lung injury in an animal model. ⋯ We may say that in the model of hemorrhagic shock-induced acute lung injury, it was found that erdosteine has a protective effect on lung tissue.