Haemophilia : the official journal of the World Federation of Hemophilia
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Observational Study
Acquired von Willebrand syndrome in patients with overt hypothyroidism: a prospective cohort study.
Numerous case reports have been published on acquired von Willebrand syndrome (aVWS) in patients with hypothyroidism, but no prospective studies have been published. The aim of this study was to investigate laboratory and clinical characteristics of aVWS in patients with newly diagnosed overt hypothyroidism. An observational cohort study was performed between May 2007 and February 2012. ⋯ Bleeding score was negatively correlated with both VWF:Ag (β -0.32, P = 0.03) and VWF:RCo (β -0.32, P = 0.02). After restoration of euthyroidism, VWF:Ag had significantly increased by 44%, VWF:RCo by 36%, factor VIII by 39%, and endogenous thrombin potential by 10%. aVWS has a high prevalence in hypothyroid patients. Highest bleeding scores in patients with lower VWF levels suggest clinical relevance.