Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · May 2005
What factors are important to parents making decisions about neonatal research?
Although parents of neonates with congenital heart disease are often asked permission for their neonates to participate in research studies, little is known about the factors parents consider when making these decisions. ⋯ Addressing parental decision making in the light of these reasons could enhance the parental permission process for parents of critically ill neonates.
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 2005
Why is there a modifying effect of gestational age on risk factors for cerebral palsy?
To investigate risk factors for cerebral palsy in relation to gestational age. ⋯ Inflammatory processes, including pre-eclampsia, are important in the aetiology of cerebral palsy. The apparent reduced risk of cerebral palsy associated with pre-eclampsia in very preterm infants is driven by the characteristics of the gestation matched control group. Use of the term "protective" in this context should be abandoned.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Randomized Controlled Trial Multicenter Study Clinical TrialRandomised controlled trial evaluating effects of morphine on plasma adrenaline/noradrenaline concentrations in newborns.
To determine the effects of continuous morphine infusion in ventilated newborns on plasma concentrations of adrenaline (epinephrine) and noradrenaline (norepinephrine) and their relation to clinical outcome. ⋯ Continuous morphine infusion significantly decreased plasma noradrenaline concentrations in ventilated newborns compared with placebo treatment. The results of this study support the idea that routine morphine administration decreases stress responses in ventilated neonates.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Randomized Controlled Trial Clinical TrialObtaining pulse oximetry data in neonates: a randomised crossover study of sensor application techniques.
Pulse oximetry may be useful during neonatal resuscitation. A randomised crossover study was performed to determine the most efficient method of applying the sensor. Applying it to the infant before connecting to the oximeter resulted in quickest acquisition of accurate heart rate. This technique should be preferred during resuscitation.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2005
Multicenter StudyBenefit of antenatal glucocorticoids according to the cause of very premature birth.
In this observational study performed in a large cohort of very preterm singletons, respiratory outcome was found to be strongly dependent on the cause of premature delivery. Although less apparent in infants born to mothers with chorioamnionitis, exposure to antenatal glucocorticoids remained significantly associated with a decrease in the incidence of respiratory distress syndrome after adjustment for the main cause of premature birth.