Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 1997
Clinical Trial Controlled Clinical TrialDiagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants.
To evaluate the commonly used markers--namely IL-6, TNF alpha, IL-1 beta, C-reactive protein and E-selection for identification of late onset neonatal sepsis; to define the optimal cutoff value for each marker in preterm neonates; to assess whether these markers could assist in early discontinuation of antibiotics in non-infected cases; and to delineate the profile of these markers during systemic infection and in relation to successful treatment. ⋯ Optimal cutoff values for these markers in detecting late onset systemic infection in very low birthweight infants have been defined. Withholding antibiotic treatment at the onset of infection could be fatal and is not recommended, but the concomitant use of IL-6 and C-reactive protein or TNF alpha should allow antimicrobial treatment to be discontinued at 48 hours without waiting for microbiological results, provided that the infants are in good clinical condition.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1997
Randomized Controlled Trial Clinical TrialCisapride reduces neonatal postoperative ileus: randomised placebo controlled trial.
To assess the efficacy of cisapride in reducing ileus persisting to the tenth postoperative day after neonatal abdominal surgery. ⋯ Cisapride is effective in neonates with a prolonged ileus after abdominal surgery.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1997
Randomized Controlled Trial Comparative Study Clinical TrialRandomised controlled trial: comparison of colloid or crystalloid for partial exchange transfusion for treatment of neonatal polycythaemia.
To compare the efficacy of using isotonic saline (crystalloid) or 5% albumin (colloid) as replacement fluid in partial exchange transfusion (PET) for the treatment of neonatal polycythaemia. ⋯ Both isotonic saline and 5% albumin are effective when used as replacement fluid in PET for the treatment of neonatal polycythaemia. Isotonic saline, which is cheaper and free of infection, should be the replacement fluid of choice.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1997
Comparative StudyImproved outcome into the 1990s for infants weighing 500-999 g at birth. The Victorian Infant Collaborative Study Group.
To compare the survival and sensorineural disability rates in extremely low birthweight (ELBW) (500-999 g) infants born in 1991-2 with ELBW babies born in 1979-80 and 1985-7, and with normal birthweight infants born in the same time periods. ⋯ Survival rates for ELBW babies in Victoria have progressively improved since the late 1970s. Sensorineural outcome for survivors born in 1985-7 has also improved compared with those born in 1979-80. However, there is no evidence that further reductions in adverse sensorineural outcomes into the 1990s, and these, as well as disabilities remain higher in ELBW than in normal birthweight babies.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jul 1997
Randomized Controlled Trial Comparative Study Clinical TrialPulmonary function changes after nebulised and intravenous frusemide in ventilated premature infants.
To compare the effects of a single dose of frusemide administered either intravenously or by nebulisation on pulmonary mechanics in premature infants with evolving chronic lung disease. ⋯ Single dose nebulised frusemide improves pulmonary function in premature infants with evolving chronic lung disease without adverse effects on fluid and electrolyte balance.