The journals of gerontology. Series A, Biological sciences and medical sciences
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J. Gerontol. A Biol. Sci. Med. Sci. · Oct 2020
Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general older population) is unclear. We estimated associations between preexisting diagnoses and hospitalized COVID-19 alone or with mortality, in a large community cohort. ⋯ There are specific high-risk preexisting comorbidities for COVID-19 hospitalization and related deaths in community-based older men and women. These results do not support simple age-based targeting of the older population to prevent severe COVID-19 infections.
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J. Gerontol. A Biol. Sci. Med. Sci. · Sep 2020
Observational StudyDisparities in Acute Pain Treatment by Cognitive Status in Older Adults with Hip Fracture.
We examined the disparities in emergency department (ED) pain treatment based on cognitive status in older adults with an acute hip fracture. ⋯ Among older adults presenting to the ED with acute hip fracture, cognitive impairment was independently associated with lower likelihood of receiving analgesia and lower amount of opioid analgesia.
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J. Gerontol. A Biol. Sci. Med. Sci. · Sep 2020
Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study.
In December 2019, the coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. In this study, we aimed to describe the clinical course and outcomes of older patients with COVID-19. ⋯ In the recent outbreak of COVID-19, our local hospital in Wuhan found that patients aged 65 and older had greater initial comorbidities, more severe symptoms, and were more likely to experience multiorgan involvement and death, as compared to younger patients.
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J. Gerontol. A Biol. Sci. Med. Sci. · Sep 2020
Clinical Characteristics of Hospitalized Individuals Dying With COVID-19 by Age Group in Italy.
Aim of the present study is to describe characteristics of COVID-19-related deaths and to compare the clinical phenotype and course of COVID-19-related deaths occurring in adults (<65 years) and older adults (≥65 years). ⋯ Individuals dying with COVID-19 present with high levels of comorbidities, irrespective of age group, but a small proportion of deaths occur in healthy adults with no preexisting conditions. Non-respiratory complications are common, suggesting that the treatment of respiratory conditions needs to be combined with strategies to prevent and mitigate the effects of non-respiratory complications.
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J. Gerontol. A Biol. Sci. Med. Sci. · Sep 2020
Randomized Controlled Trial Multicenter StudyEffect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial.
Fatigue often triggers screening for and treatment of subclinical hypothyroidism. However, data on the impact of levothyroxine on fatigue is limited and previous studies might not have captured all aspects of fatigue. ⋯ Levothyroxine in older adults with mild subclinical hypothyroidism provides no change in physical or mental fatigability.