American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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Am J Health Syst Pharm · Jul 2013
Multicenter StudyBiological contamination of insulin pens in a hospital setting.
Biological contamination of insulin pens in a hospital setting was studied. ⋯ Examination of 125 insulin pens used in hospitals revealed hemoglobin in 1 pen and at least one cell in another 6 pens. The nine detected cells consisted of four squamous epithelial cells, four macrophages, and one RBC.
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Am J Health Syst Pharm · Jul 2013
ReviewVemurafenib and ipilimumab: new agents for metastatic melanoma.
The development and place in therapy of vemurafenib and ipilimumab for the treatment of metastatic melanoma are reviewed. ⋯ Vemurafenib and ipilimumab are important advances in the treatment of metastatic melanoma. Benefit is typically short lived for vemurafenib and uncommon for ipilimumab. Neither agent is curative, and clinical trials remain an alternative first-line treatment option.
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Am J Health Syst Pharm · Jul 2013
Comparative StudyPreapproval and postapproval availability of published comparative efficacy research on biological agents.
Preapproval and postapproval availability of published comparative efficacy studies on biological agents approved between 2000 and 2010 was investigated. ⋯ Nearly half of all biological agents approved for marketing between 2000 and 2010 lacked publicly accessible, active-controlled efficacy studies at the time of drug approval; a slightly greater proportion of biological agents had comparative efficacy data published subsequent to their approval.
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Am J Health Syst Pharm · Jul 2013
ReviewAn integrated approach to research and manuscript development.
A stepwise process for planning, writing, and submitting a research manuscript to a peer-reviewed journal is described. ⋯ The process of writing and securing journal acceptance of manuscripts should proceed along a well-defined pathway integrating all research and writing tasks. Close adherence to the target journal's instructions for authors and prompt response to reviewer comments help avoid delays in the publication of accepted articles.