American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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Am J Health Syst Pharm · Jan 2017
ReviewRole of agents for reversing the effects of target-specific oral anticoagulants.
The available clinical data on target-specific oral anticoagulant (TSOAC) reversal agents that are currently in development or have been approved by the Food and Drug Administration (FDA) are reviewed. ⋯ Idarucizumab and other TSOAC reversal agents, such as andexanet alfa and ciraparantag, present the potential for consistent and effective treatment and management options when life-threatening or uncontrolled TSOAC-associated bleeding occurs or when emergency surgery is warranted in patients using TSOACs.
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Am J Health Syst Pharm · Jan 2017
Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration.
The physical compatibility of isavuconazonium sulfate with 95 i.v. drugs during simulated Y-site administration was studied. ⋯ Of the 95 drugs tested, isavuconazonium sulfate 1.5 mg/mL was physically compatible with 66 drugs in 0.9% sodium chloride injection and 60 drugs in 5% dextrose injection. Incompatibility was observed with 18 antimicrobials, including most cephalosporins tested, and 14 other i.v. drugs in at least 1 of the 2 tested diluents.
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Am J Health Syst Pharm · Dec 2016
Review Meta AnalysisMeta-analysis of ascorbic acid for prevention of postoperative atrial fibrillation after cardiac surgery.
Results of a systematic review and meta-analysis of published data on use of ascorbic acid to prevent postoperative atrial fibrillation (POAF) after cardiac surgery are presented. ⋯ A meta-analysis revealed that, compared with use of a placebo or a nonplacebo control, perioperative administration of ascorbic acid to patients undergoing cardiac surgery was associated with a reduced frequency of POAF and a shorter ICU LOS and total hospital LOS.